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KMID : 0942820030020020086
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Journal of Korean Brain Tumor Society
2003 Volume.2 No. 2 p.86 ~ p.89
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Brain Metastasis of Unknown Primary Tumor
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Jeon Jin-Ho
Lee Sang-Weon
Choi Byung-Kwan
Cha Seung-Heon
Song Geun-Seung
Choi Chang-Hwa
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Abstract
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Background: The prognosis of patients with brain metastasis of unknown primary tumor is controversial. The authors reviewed the results of gross total resection with radiotherapy in this group of patients.
Methods: Between 1993-2000, 133 patients admitted to the study department for the treatment of metastatic brain tumor. Gross total resection was done in 33 patients with single brain lesion. Ten patients had solitary brain metastasis without a detectable primary site despite extensive systemic evaluation(Group I), and remaining 23 had previous cancer history or a detectable primary lesion(Group II). Survival analysis and comparison was done.
Results: The median survival was 24.1months in group I(range, 6.5-58.5) and 19.0months in group II(range, 4.7- 40.6). The overall survival for group I was better than group II, but not significant. Adenocarcinoma was the most common histology of group I. During the follow-up the primary tumor was found in 7 patients and was located in the lung in 4 patients.
Conclusion: Brain metastasis of unknown primary tumor has better prognosis than that of brain metastasis in general. Gross total resection with radiotherapy for local disease control is effective in this group of patients especially in solitary lesion.
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KEYWORD
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Brain metastasis, Unknown primary tumor, Gross total resection, Radiotherapy
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